First a mea culpa, I have a huge backlog of relatively heavy articles that I really want to add to the blog. But I’ve been busy getting married – congratulations to me – and I didn’t have enough time. I strongly believe in following relatively strict guidelines on writing and editing articles, where I set myself deadlines and avoid over-writing on topics – it is just a blog after all – but for deep insights I do also have a minimum standard that I want to be able to produce before I’m willing to hit the Publish button.Continue reading “Build – Test – Move”
I am beginning a new project this week, the topic is Causal Inference. This is something I have been reading about, and wrestling with, for quite some time. Now seems a good point to take some time out, form a project, and see what I can get done on the topic.Continue reading “New Project: Causal Inference”
Today is my last official day under contract to Fosanis GmbH. I had my first encounter with the founders following my talk at the Digital Health Forum in March 2018. Following that initial meeting I became an advisor, writing a major funding proposal, bringing scientific techniques to the core of the product. In November 2018, following the closure of my own company, I became a full-time member of staff – as Head of Data Science – and led the project on the basis of the ideas contained in my funding proposal.Continue reading “Closing a Chapter @ Fosanis”
I sometimes see myself as a slow learner. I am extremely fast at deep-thinking, which somewhat disguises this fact, but I learn things from the ground up. Until I can think a topic through I sometimes feel unsure about operating from an incomplete understanding.
When I worked in academia I prefered to learn rather than to force my opinions on others. Everybody seemed reasonably smart, and they were absolutely convinced of their own correctness, and so I listened and learned. Continue reading “Why I write”
This topic occurred to me following my recent talk at a dental conference at Charité Berlin. Upon hearing that I have a strong interest in inference, my fellow keynote mentioned that it drives him crazy that random forests, and similar algorithms, work so much better than DNNs on genomic data. He challenged me to come up with a reason for why this is the case.
I think that I know why. The problem I have is that I suspect that I can never prove it. That issue of not being able to prove things in machine learning is probably an equally interesting topic, for a future article, but here I want to address my theory of why random forests work better than DNNs for analysing genome data.Continue reading “Why do Trees work better than DNNs on genome data?”
A sense of home is a powerful feeling. The sense of belonging, of knowing where everything is. I miss that sometimes.
I left Ireland almost exactly 10 years ago with a burning need to go out and prove myself. I had finally recovered from Chronic Fatigue Syndrome and was going to take up a much delayed PhD position. I moved to the University of Luebeck, where I found my introduction to neuroscience, before moving on to Paris Descartes, the École Normale Supérieure and the University of Chicago. With each move I developed a new network of colleagues, collaborators, and mentors.
A couple of weeks ago I was contacted by a member of the Irish mathematical community. Many years ago I wrote the website for the Mathematics Department at NUI, Galway. While doing that I included biographies of the then members of staff and their research domains. At some point, I also made a backup of the website for my own reference under my personal domain. Sadly, many of the members of staff who worked at NUI, Galway when I was an undergraduate are now dead. So now this resource has become a useful archive. And thus I was re-discovered by a member of the current Irish mathematical community.Continue reading “The network you grow up with”
How do I really feel about this topic? I think that I can only work out the answer to this question by writing about it.
My suspicion is that those who shout loudest about personalised medicine know least about it. I fear that the promises being made publicly are categorically not possible. My hope is that I am wrong on this.Continue reading “Personalised Medicine – A statistical theory approach”
Apparently, it’s that time again. I just gave my second invited keynote at a conference at Charité Berlin. It was really fun.
The audience were dentists – academic dentists. I confess that I struggled to understand why they thought I would be a good fit for their conference. My previous keynote was at the BIH Digital Health Forum – a much more obviously appropriate audience. But, perhaps strangely, the fit was very good.Continue reading “Keynote @ Charité Berlin”
When I sat down in Summer 2018 to begin my blog one of my goals was to write approximately 5 definitive articles about Mathematics and Biology. So far, I have been pretty hard on the efforts in both fields to come together. I began with a review of the very different world-views inherent in the two subjects – combined with a call to arms for likeminded people to come and help out. I followed this with a more practical consideration of the repertoire of techniques necessary and the career constraints, which actively work against combining these two disciplines. Today I want to consider the shining example of bioinformatics – the one area in which mathematics is clearly being used in biology and which demonstrates a clear career path.Continue reading “Mathematics and Biology III – Bioinformatics”
One year ago I finally picked up the courage to put my thoughts publicly online. I led with a traditional Hello World but I quickly followed-up with my opening manifesto for the company I was trying to establish Simmunology.
The discipline of writing is something I initially discovered, when I first moved to Germany, 10 years ago. It clarifies my thoughts and allows me to discover the holes in my own thinking.
Blogging has paid off immensely. Before, I was afraid of sharing my thoughts and having my opinions come back to bite me. This sometimes led me to go too far down paths that I didn’t agree with.
Eventually I had to accept that I have accumulated considerable life experience. And that those to whom I was listening had typically less things of importance to say than I do. Finally, if I put it here and you disagree with me – I might change my mind – it will certainly lead to a more aligned working relationship.